Vol. 6, Issue 1, Part A (2024)

Hemophagocytic syndrome (HPS), also known as hemophagocytic lymphohistiocytosis (HLH), is a rare but life-threatening condition characterized by excessive immune activation and subsequent tissue damage. The occurrence of HPS during pregnancy presents unique diagnostic and therapeutic challenges due to overlapping symptoms with other pregnancy-related conditions and the need to balance maternal and fetal health. This review aims to provide an overview of the pathophysiology, clinical presentation, diagnostic criteria, and management strategies for HPS in the context of pregnancy.