Vol. 6, Issue 1, Part A (2024)

Hyperemesis gravidarum affects 0.3-1.5% of pregnancies. Psychological, physiological, and anatomical factors can cause hyperemesis gravidarum. Helicobacter pylori may cause hyperemesis gravidarum. Pregnancy may prolong gastric emptying dysmotility and intestinal transit time, favoring H. pylori infection. This study aimed to find the association between hyperemesis gravidarum in 1st trimester pregnancy and H. pylori. In this case-control study, 50 pregnant women with hyperemesis gravidarum and 50 healthy pregnant women were studied at Tikrit Teaching Hospital in Iraq from October 1, 2023, to June 30, 2024. The commonest age group in cases group was 20-29 years 19 (38%), and ≥ 30 years 18(36%). Positive H. pylori IgG found among 39 (39%) of the pregnant women. Positive H. pylori IgG found significantly higher among cases 29 (58%) than control group 10(20%). Serum H. pylori IgM found among 32(64%) of the cases and 12(24%) of the controls. High serum Na level found among 5(10%) of the cases and 5(10%) of the controls, low serum Na level found among 18(36%) of the cases and 4(8%) of the controls, this relation was statistically significant. High serum K level found among 0(0%) of the cases and 2(4%) of the controls, low serum K level found among 15(30%) of the cases and 1(2%) of the controls, this relation was statistically significant. The hemoglobin level of 7-9 found among 7(14%) of the cases and 4(8%) of the controls, the level of 10-11 g/dl found among 20(40%) of the cases and 15(30%) of the controls.