Vol. 7, Issue 1, Part A (2025)

Caesarian Section (CS) is the most frequently performed surgical technique internationally, accounting for around 15% of all births worldwide. The increasing use of Caesarian sections in recent years has coincided with a greater incidence of postoperative problems, particularly with wound healing and scarring. Clinical research has investigated the efficacy of PRP in tissue repair and analgesia; nevertheless, the findings remain inconsistent and unconvincing. These discrepancies highlight the need for additional, targeted research, especially among high-risk populations, to determine the impact of PRP on improving caesarian wound healing and reducing pain. This randomized clinical study sought to assess the effectiveness of autologous platelet-rich plasma (PRP) in expediting wound healing and alleviating postoperative pain after caesarian delivery in high-risk pregnancies. One hundred women with elevated BMI, diabetes, or multiple gestations were randomized (1:1) to receive subcutaneous PRP injection before skin closure (N=50) or no PRP (N=50). Wound healing was evaluated utilizing the REEDA scores, the Vancouver Scar Scale (VSS), and the Visual Analogue Scale (VAS) for pain on surgical days 1, 5, and 2 months thereafter. The PRP group had significantly superior results relative to the control group, as seen by reduced REEDA and VSS scores and better wound approximation. The PRP group demonstrated significantly reduced pain ratings. The results indicate that PRP is both safe and effective, possibly acting as a valuable adjunct to enhance postoperative rehabilitation and minimize problems following caesarian sections in high-risk women.